Improved Functionality of Exhausted Intrahepatic CXCR5+ CD8+ T Cells Contributes to Chronic Antigen Clearance Upon Immunomodulation
Chronic hepatotropic viral infections are characterized by exhausted CD8+ T cells in the presence of cognate antigen in the liver.The impairment of T cell response limits the control of chronic hepatotropic viruses.Immune-modulatory strategies are attractive options to re-invigorate exhausted T cells.However, in hepatotropic viral infections, the k